American actress Kaley Cuoco has said she “will never get married again” following her second divorce.

Cuoco, 36, rose to fame as Penny in the hit US sitcom The Big Bang Theory and most recently starred in Emmy-nominated black comedy The Flight Attendant, which returns for its second series later this month.

Speaking to Glamour US, Cuoco said: “I will never get married again, I would love to have a long-lasting relationship or a partnership.

“But I will never get married again. Absolutely not.”

Cuoco has been married twice, first to American tennis player Ryan Sweeting, who she divorced in 2016 and then to equestrian star Karl Cook.

In September 2021, Cuoco and Cook announced they had filed for divorce after three years of marriage.

In a statement at the time, the couple said: “Despite a deep love and respect for one another, we have realised that our current paths have taken us in opposite directions… There is no anger or animosity, quite the contrary.”

Despite her certainty that she will never walk down the aisle again, Cuoco revealed that she has by no means ruled out falling in love again.

“I love love,” she told Glamour.

“I’m not someone that wants to be by myself. I just need to figure out my priorities a little bit and make sure now I know that I need to water that relationship.

“It’s like a plant. Sometimes I get too focused on the garden instead of the specific plant that needs to be watered. And I am well aware of that. I want to change, I want to be better.”

Cuoco also spoke candidly about the physical effects filming the second series of The Flight Attendant while also going through a divorce had on her body.

She said: “I’d have these emotional scenes and then I’d go home and cry over my personal life.

“I developed a rash that went from my lower stomach down my leg. It lasted for seven months.

“I discovered through therapy and through my doctors that it was completely emotional. That’s how the stress was [showing up] physically. I couldn’t even walk. The scenes were so hot and driven; there was no calmness.”

Cuoco revealed she is receiving therapy in an effort to stop being so “black and white,” and to start thinking about the possibility of having a successful relationship in the future.

“I’m so black-and-white, and trying to find the gray is just very hard for me,” she said.

“I want to have a relationship that I give my time to and that the person feels [like they’re] really part of my life. I get so distracted with work and I want to have that in the future.”

She added: “I really know where I’ve f***** up, and I don’t want to do that again.”